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As yet, we are not in a possession of astrocyte-specific therapies or drugs

Ploss, O

Hydrogen peroxide is subsequently broken down by two pathways

Quercetin is a natural flavonoid with many biological activities and pharmacological effects

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Additionally, the role of non-classical ferroptosis suppressors (e.g., FSP1, DHODH, and GCH1/BH4) in ADPKD is entirely unexploredwhether these pathways compensate for GPX4 downregulation in cystic kidneys or if their dysfunction exacerbates ferroptosis susceptibility remains unknown, limiting the development of multi-targeted interventions