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Whilst the NHS notes that taking up to 2,000 micrograms daily is unlikely to cause harm in most people, there is generally no benefit to consuming such excessive amounts unless treating confirmed deficiency under medical supervision

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doi:10.1098/rsbm.2002.0011

Supplementation with NAD + could slow down axonal degeneration and demyelination, but did not change the level of macrophage infiltration after amputation

IV, IM, or Subcutaneous injection supplementation supports the energy systems that hormone optimization also targets