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It is worth noting that YAP1 has different effects on tumor and peritumoral

Acknowledgments The work was performed under the CNCSIS grant PD 132/30.07.2010 (PD 29/2010)

Although adverse reactions to intravenous, intramuscular or subcutaneous injection of 0.9% benzyl alcohol are not known to occur in man, experimental studies of small volume parenteral preparations containing 0.9% benzyl alcohol in several species of animals have indicated that an estimated intravenous dose up to 30 mL may be safely given to an adult without toxic effects

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Increased mitochondrial fission is critical for hypoxia-induced pancreatic beta cell death

In primary epithelial ovarian cancer (EOC) specimens, SHMT1 and SHMT2 expression is markedly elevated, and combining chemotherapy with SHMT inhibitors demonstrates potent antitumor efficacy [84]