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95% CI 1.242.01

Management, therefore, focuses on identifying elevated Lp(a), intensifying control of all modifiable risk factors, lowering LDL-C or ApoB aggressively when appropriate, and considering PCSK9 inhibitor therapy in selected high-risk patients because monoclonal PCSK9 inhibitors modestly lower Lp(a) while substantially lowering LDL-C

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Animal studies further highlight that prebiotic supplementation enhances detoxification enzyme activities and reduces oxidative stress markers in the liver, underscoring their therapeutic potential in liver health

Control of metabolic and cardiovascular function by the leptin-brain melanocortin pathway

Transcription factor EB (TFEB), a master regulator of the autophagy-lysosomal pathway, downregulates NLRP2 inflammasome via CMA activation (Song et al., 2021)