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Given its role in neuronal survival and apoptosis, the MAPK pathway has become a key area of interest in SCA3 drug discovery

Nat Rev Endocrinol (2017) 13:62728

Conversely, a Mendelian randomization study suggested a causal relationship, identifying Chemokine (C-C motif) Ligand 19 (CCL19) as positively associated with tinnitus risk (Chen and Cai, 2025)