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Some hormone-targeting medications do show reduced effectiveness over time as receptors downregulate in response to sustained activation

doi: 10.1016/j.exer.2016.04.023 58

I., Metwally, M

The Evidence Gap: What Science Actually Says (and Doesnt Say) While BPC-157 and TB-500 are widely hyped online, the scientific support is limited almost entirely to animal studies and cell models