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BENZODIAZEPINE WITHDRAWAL SYMPTOMS PSYCHOLOGICAL SYMPTOMS Excitability (jumpiness, restlessness) Insomnia, nightmares, other sleep disturbances Increased anxiety, panic attacks Agoraphobia, social phobia Perceptual distortions Depersonalisation, derealisation Hallucinations, misperceptions Depression Obsessions Paranoid thoughts Rage, aggression, irritability Poor memory and concentration Intrusive memories Craving (rare) PHYSICAL SYMPTOMS Headache Pain/stiffness (limbs, back, neck, teeth, jaw) Tingling, numbness, altered sensation (limbs, face, trunk) Weakness (jelly-legs) Fatigue, influenza-like symptoms Muscle twitches, jerks, tics, electric shocks Tremor Dizziness, light-headedness, poor balance Blurred/double vision, sore or dry eyes Tinnitus Hypersensitivity (light, sound, touch, taste, smell) Gastrointestinal symptoms (nausea, vomiting, diarrhoea, constipation, pain, distension, difficulty swallowing) Appetite/weight change Dry mouth, metallic taste, unusual smell Flushing/sweating/palpitations Overbreathing Urinary difficulties/menstrual difficulties Skin rashes, itching Fits (rare) These symptoms have all been described by patients withdrawing from benzodiazepines

In a diseased state, TDP-43 is found mislocalized from the nucleus and aggregated in the cytoplasm of neurons within the central nervous system (CNS) in ~ 97% and ~ 45% of ALS and FTD cases, respectively [3, 4]

The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling

CGA drastically increased the release activity of the InsP(3)R by increasing the channel open probability by 9-fold and the mean open time by 12-fold

[6] In fact, azelaic acid is sometimes recommended as a safer alternative to hydroquinone during pregnancy for managing melasma or dark spots, given its favorable safety profile

doi: 10.1038/s41388-022-02364-0