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J.MartinezC.NieslerB.van der VoortI.MonnikesH.StengelA.et al (2020)

In a clinical trial on 6 men, drinking coffee (165-400 mL/day) increased gallbladder contractions and the levels of the hormone that stimulates bile release (cholecystokinin) [2, 21]

A commonly extrapolated human-equivalent dose is roughly 2 to 10 micrograms per kilogram, though no human dose-ranging trial has been completed or published

Aberrant Rab11dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease

Even your morning coffee might be contributing to the problem, as caffeine can increase muscle tension and teeth grinding