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Mechanical rubbing to remove eye makeup is one of the most significant contributors to periocular skin damage over time

Neurology 86 , 10701071 (2016)

Musto JA, Palmer G, Nemer M, Schell T, Waclawik G, Glover Q, et al

Selenocysteine is one such example (sometimes even thought of as the 21st amino acid) and is unique for multiple reasons, specifically that its the only amino acid that contains an essential nutrient, selenium