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Aspartame and the hippocampus: Revealing a bi-directional, dose/time-dependent behavioural and morphological shift in mice. Neurobiol Learn Mem

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Increased glutamate release leads to motor neuron hyperexcitability, aberrant firing, increased intracellular calcium, and cell death [312]

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Iron is transported by cells in two forms, Tf bound and non-Tf-bound iron

In vitro cytotoxicity and cell apoptosis assays confirmed the safety of DBP, while radical scavenging assays and measurements of intracellular reactive oxygen species (ROS) demonstrated its strong antioxidant capacity