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The authors are thankful to the Deanship of Graduate Studies and Scientific Research at the University of Bisha for supporting this work through the Fast-Track Research Support Program

These findings suggest that genisteins neuroprotective ability against apoptosis in this model appears to be mediated through estrogen receptor signaling, similar to 17-estradiol

J Am Chem Soc 122:1046810469 Turk H, Erdal S, Genisel M, Atici O, Demir Y, Yanmis D (2014) The regulatory effect of melatonin on physiological, biochemical and molecular parameters in cold-stressed wheat seedlings

High-dose free curcumin exhibits dose-dependent hepatotoxicity, mechanistically arising from mitochondrial dysfunction, ROS overproduction, and activation of necroptosis pathways involving RIPK1/RIPK3 complexes in hepatic cells [74]

330(6): E759

ATM, ATR, and DNA-PK: the trinity at the heart of the DNA damage response