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In addition to extracellular catabolism, intracellular GSH degradation is mediated by the ChaC GSH specific gamma-glutamylcyclotransferase family (CHAC1 and CHAC2), which cleaves GSH into 5-oxoproline and Cys-Gly 28,29

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Nuclear factor kappaB-dependent neurite remodeling is mediated by Notch pathway

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Weeks 13 To 16 : 1.7 mg once weekly This is a higher step in the escalation process