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M.ParkinsonE

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Alcohol also increases TGF-1 expression while inhibiting granulocyte/macrophage colony-stimulating factor (GM-CSF) in the alveolar space, both of which have been implicated in disrupting and increasing the permeability of the alveolar epithelium (77, 110, 111)

Due to the direct binding of Asn35 to EA, the IC 50 value of N35D was 10-fold greater than that of WT, whereas the IC 50 values of N35A and N35Q were 70- and 160-fold greater than those of WT (Table 1), indicating that the structural specificity of the side-chain of Asn35 is crucial for EA binding