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For instance, VLX-600 dually targets iron and OXPHOS to promote autophagy-mediated cell death in glioblastoma cells, suggesting an interesting novel strategy to combat high OXPHOS cancer cells [101]

Shao YY, Chen PS, Lin LI, Lee BS, Ling A, Cheng AL, et al

Despite promising Phase 2 results and an excellent safety profile, the compound could not demonstrate sufficient efficacy in the larger confirmatory trial to justify the investment required for continued pharmaceutical development toward regulatory approval

Holotransferrin binds to its receptor on the hepatocyte, where it can make a molecular complex with HJV

Zinc metalloprotease proA from legionella pneumophila inhibits the pro-inflammatory host response by degradation of bacterial flagellin

R.MackaaijC.van LeeuwenM