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In addition to MC1R, -MSH interacts with melanocortin receptors MC3R, MC4R, and MC5R, contributing to a wide spectrum of physiological effects

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Cessation of habits, improving oral hygiene, increasing dietary roughage and elimination of implicated medications, if possible, are recommended

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Factors considered in differential diagnosis include: By using all these steps, doctors can find out why your lips are darker

Cases of multiple lesions of the respiratory tract by primary bronchial melanoma have also been described