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That means for every milligram you inject, roughly 0.8mg reaches systemic circulation in active form

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doi: 10.1016/j.intimp.2024.113187 Summary Keywords gouty arthritis, disease staging, proteomics, validation, joint cavity effusion, tophi, ferroptosis Citation Xiao N, Lu H, Zeng S, Yan H, Yang Q, Sheng L, Chen B, Xu Y, Zhang J, Xie J, Zhou W, Li Z and Xie Z (2026) Exploring the inflammatory origins of gouty arthritis: mechanistic studies based on local lesion proteomics and validation