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The more depleted your body is, the more time and consistent supplementation it will take to feel the full effects

Plant Physiol 154(4):16461658 Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 CT method

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Growth hormone secretion follows a circadian pattern, with the largest pulses occurring shortly after the onset of deep sleep. Van Cauter et al., Journal of Clinical Investigation Best Times to Administer Sermorelin Before Bed (Most Common) Administering Sermorelin 30 minutes before sleep helps amplify the bodys largest natural GH pulse , leading to better recovery and fat metabolism during the night