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Some studies indicate that DSIP may influence endogenous opioid signaling, although its effects are not consistently reversed by opioid antagonists, suggesting indirect modulation rather than direct receptor agonism [9]

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Wang X, Liu B, Xu Q, Sun H, Shi M, Wang D, Guo M, Yu J, Zhao C, Feng B

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Some are thoughtfully designed, clinically supervised, and used with clear goals