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TARGETS OF PHARMACOTHERAPY IN THE MANAGEMENT OF OBESITY Novel insights provided by pathophysiology indicate the presence of a complex homeostatic system in which information about the energy reserve status and the meal quality and content is relayed from the periphery (gastrointestinal tract, pancreas, and adipose tissue) via specific orexigenic and anorexigenic peptides and hormones to the central nervous system (CNS)

The conversions of cobalamins from different extractions were monitored by determining the contents of total B12 in the pork fillet sample applying SIDA as well as observing the peaks of unconverted OHCbl, AdoCbl, and MeCbl in the LC-MS/MS chromatograms

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