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Fluoxetine reduces the mRNA expression of c-Fos through the PI3K/AKT signaling pathway after acute application at concentrations below 1 M, while the treatments with the higher doses (above 5 M), it increases the gene expression of c-Fos via the MAPK/ERK signaling pathway in astrocytes

10.1677/JOE.1.05646 47 KociuszkoM.BuczyskaA.KrtowskiA

The FDA safety communication on benzyl alcohol has more background on this

Animals were fed commercially available rodent diet [(standard diet (SD)] sourced from Top Feeds Ltd, Ibadan Nigeria)

XPOVIO Combination with Bortezomib and Dexamethasone (XVd) The efficacy of XPOVIO in combination with bortezomib and dexamethasone was evaluated in BOSTON (NCT03110562)