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When taken by mouth, B12 absorption depends largely on intrinsic factor, a protein secreted in the stomach that binds B12 and facilitates its uptake in the small intestine

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Significant ANOVA/KruskalWallis test results were then followed with post-hoc testing, which underwent the two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli correction for multiple comparisons

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When to Seek Medical Advice About B12 Levels Most individuals taking vitamin B12 supplements as directed do not require routine monitoring of serum levels unless they have specific medical conditions or are receiving treatment for documented deficiency