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doi: 10.1021/acs.jafc.8b05581 32 WangYNMengXCDongYFZhaoXHQianJMWangHYet al

However, these studies reinforce the concept that there are immediate cellular effects of estrogen in either endothelial or smooth muscle cells that alter the internal milieu of the cell resulting in altered responsiveness to subsequent stimuli (Haas et al., 2007