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ACTH is transported to the adrenal gland where it stimulates the secretion of glucocorticoids, the main one being cortisol

By inhibiting their reuptake, tesofensine increases the availability of these neurotransmitters in the brain

Nat Rev Neurosci 2:727733 Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG (2000) ?-opioid receptor desensitization by -arrestin-2 determines morphine tolerance but not dependence

It means products stored in temperature-controlled Canadian facilities rather than sitting in shipping containers during cross-border transit