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What is the biological mechanism explaining why cells undergo excessive autophagy

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These ferroptosis inducers specifically target engineered RAS mutant tumor cells via the RAS-BRAF (B-rapidly accelerated fibrosarcoma)-MAPK (mitogen activated protein kinase)/MEK (mitogen-activated protein kinase kinase)-MAPK/ERK (extracellular signal-regulated kinase) pathway and voltage-dependent anion channel (VDAC), inducing oxidative stress and mitochondrial dysfunction [1,36,37]

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