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M1 macrophages are typically induced by signals such as interferon-gamma (IFN-) or lipopolysaccharide (LPS) and they highly express reactive oxygen species (ROS) and nitric oxide while secreting pro-inflammatory cytokines like TNF- and IL-12 thereby contributing to pathogen clearance and anti-tumor immunity (31, 32)

Additionally, ubiquinone (also known as coenzyme Q) is a ubiquitous lipid-soluble redox cofactor that primarily transfers electrons and protons across the inner mitochondrial membrane[78]

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Progressive multifocal leukoencephalopathy and anti-CD20 monoclonal antibodies: what do we know after 20 years of rituximab