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Cabotegravir is primarily metabolized by UGT1A1, with some contribution from UGT1A9, and rilpivirine is primarily metabolized by CYP3A Drugs that are inducers and inhibitors of UGT1A1, UGT1A9, or CYP3A may affect plasma concentrations of CABENUVA No drug interaction studies were conducted with CABENUVA

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