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These analyses are then presented to the Ontario Health Technology Advisory Committee, whose mandate is to examine proposed health technologies in the context of available evidence and existing clinical practice, and to provide advice and recommendations to Ontario health care practitioners, the broader health care system, and the Ontario Ministry of Health and Long-Term Care

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Initially, the mechanisms of action of this enzyme were considered paradoxical because CD38 is predominantly localized on the cell surface, yet its final products are utilized within cytoplasmic compartments

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[6] After parenteral delivery, cyanocobalamin binds transcobalamin II, permitting receptor mediated endocytosis into virtually all nucleated cells