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Recently, evidences from clinical studies such as NCT01811992 adenoviral vector-based combination (cytotoxic and immunotherapy) therapy for HGG showed no treatment release deaths indicating the safety of viral vectors for therapeutic applications [165]

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cerevisiae can be further increased by strategies of metabolic engineering and fed-batch fermentation, the highest content of ergothioneine were reported to reach 1.31 g/L [15] and 2.39 g/L [20] respectively

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The regulatory framework anchored by FDAs 2003 BA/BE guidance and 2002 CMC guidance, and USP General Chapter defines precise measurement requirements, lifestage sampling protocols, and statistical approaches for both brand-name NDA and generic ANDA development programs

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