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The tip of the Cryopen may reach as low as -89C which creates a rapid drop of temperature in the tissues

Although multiple data support a functional role of distinct cutaneous microbes in modulating epidermal tumor formation, the involvement of the skin microbiome in tumorigenesis remains relatively underexplored despite increasing research efforts

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Intracellular changes in fibrosis-associated cells Progression of fibrosis due to oxidative stress imbalance Ionizing radiation is known to cause cellular damage through oxidative stress (Fig