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NLRP3 inflammasome activation triggers Caspase-1-mediated mitochondrial damage, characterized by increased mtROS production, mitochondrial swelling, and fragmentation, while also inhibiting mitophagy and amplifying mitochondrial damage [11]

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Hypothyroidism contributes to anxiety by disrupting thyroid hormone levels, which are essential for regulating neurotransmitters like serotonin that maintain mood stability