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Similarly, in patients with carnitine-acylcarnitine translocase deficiency (CACTD), the carnitine shuttle system does not function and LCFAs cannot be transported inside the mitochondrial matrix for beta oxidation

In the course of the present study, the following inhibitors of glutamate dehydrogenase were identified: epigallocatechin-3-gallate (EGCG), hexachlorophene (HCP), bithionol (BTH), GW5074, CPD-3B, ebselenin, R162, and others(Table 3)

Over 20 different KATs have been identified and can be classified into three major families that share similar structure and function: The general control non-derepressible 5 (GCN5)-related (GNAT) family, the CREB-binding protein (CBP)/p300 family and the MYST family

Specifically, copper directly interacts with GPX4 to facilitate its aggregation and subsequent autophagic degradation (137)

Improvements in metabolic markers have been observed

GSH is a thiol-based tripeptide implicated in a variety of cellular processes, including detoxification of xenobiotics and protection against ROS [11],[12]