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3.2.5 Elucidation of mechanism of action using transcriptomics Here, we explored the potential utility of transcriptomics as a technology, not only for establishing a PoD but also for gaining mechanistic insights to generate hypotheses within the context of a risk assessment framework

GSH-Mediated Metabolism and Antibiotic Susceptibility GSH-dependent metabolic pathways also contribute to the detoxification of antibiotics

The pivotal inflammatory role of this pathway is corroborated in P2Y14R-deficient mouse models (Ka et al., 2021)

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First, the causal direction in human studies remains ambiguous: it is unclear whether gut dysbiosis is a driver of OA or a consequence of its associated factors, such as reduced physical activity, diet changes, or chronic medication use