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Von Hippel-Lindau disease is a hereditary tumor syndrome and about 30%-70% of patients with VHL develop RCC, and VHL-related renal cell carcinoma is almost ccRCC

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This activates adhesion molecules (ICAM-1, VCAM-1), driving leukocyte infiltration, microvascular injury, thrombosis, and multi-organ damage

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

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