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This is particularly interesting given that mutant SOD1 reportedly promotes progressive spinal cord Cu accumulation in hSOD1 G93A mice via upregulation of Ctr1, CCS, Atox1 and Cox17 cuproprotein expression, and downregulation of ATP7A

To probe deeper into the Enterobacteriaceae family, shotgun metagenomics sequencing was also used to confirm the link of the enrichment of specific ABR genes to the possible enrichment of opportunistic pathogens

Like all neurotrophic factors, it is involved in regulating the growth, maintenance, and survival of neurons

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