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Purity: 98.85% CAS No.: 115104-28-4 Formula: C 26 H 27 ClN 2 O 3 S 2 Molecular Weight:515.09 Storage: 4C, protect from light * In solvent : -80C, 6 months

USCAP 2010 Annual Meeting, 2010

Sorafenib nanoparticles wrapped in platelet membranes can specifically target TAMs, resulting in a significant decrease in the M2/M1 ratio in a pancreatic cancer model (187, 195)

Mechanistic studies confirmed that the anti-cancer effects operate through a dual mode of action: direct suppression of tumor cell proliferation via PAK4 degradation and potentiation of anti-tumor immunity by remodeling the immune microenvironment, as evidenced by RNA-seq analysis revealing enrichment in immune-related pathways such as TNF signaling and interferon response

ElsevierCG England, MC Miller, A Kuttan, JO Trent, HB FrieboesEuropean Journal of Pharmaceutics and Biopharmaceutics, 2015Elsevier 92 , 120129 (2015)

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