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Specifically, it has demonstrated an ability to make skin more firm, reduce wrinkles, and provide anti-aging effects

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Kelly CP, Green PH, Murray JA, Dimarino A, Colatrella A, Leffler DA, Alexander T, Arsenescu R, Leon F, Jiang JG, Arterburn LA, Paterson BM, Fedorak RN

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"One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial." J Drugs Dermatol

We recommend a more assertive strategy, suggesting daily injections until no further improvement is apparent