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Example 4: Physicochemical characterization of the pre-fusion stabilized hMPV F antigen constructs [0374] To further characterize the purity, size, and thermal stability of the protein produced from the A2-D185P and A2-T160F_N46V constructs - HP-SEC, SEC-HPLC, SEC-MALS, and nanoDSF analysis was performed

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The results reported that both doses of Dihexa increased levels of AngIV in the brains of APP/PS1 mice, with the 2.88 mg/kg dose increasing these levels to almost the same amount in the wild type