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Flow Cytometric Analysis of Apoptosis After different treatments, MC3T3-E1 cells were washed with PBS and then labeled with FITC-Annexin V and PI in binding buffer according to the manufacturers instructions

Candidacy for either or both treatments requires a clinical evaluation

Pharmacological MET inhibition (e.g., crizotinib) disrupts this stromal-protective niche by blocking HGF-MET signaling, demonstrating therapeutic potential against CAF-mediated tolerance [146]