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If a vegan or vegetarian person has developed symptoms despite B12 supplements we advise him or her to see a doctor who knows about deficiency among vegans and vegetarians

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Proc Natl Acad Sc USA 82 : 18911821 Figus A et al

There may also be no meaningful improvement, even where the procedure is technically successful

Consequently, positive results in such models may overestimate therapeutic efficacy and underestimate offtarget effects