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GSH is involved in numerous vital functions such as detoxifying electrophiles, scavenging free radicals, maintaining the thiol status of proteins, providing cysteine, modulating DNA synthesis, microtubular-related processes, nitric oxide homeostasis, the activity of neuromodulators as well as immune functions (reviewed in Lu 2009)

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Beyond disulfide bonds, diselenide bonds (-SeSe-) have also been employed in GSH-responsive DDSs, owing to seleniums chemical similarity to sulfur, as both elements belong to Group VI of the periodic Table [58]

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