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When these adaptive mechanisms are overwhelmed by a chronic excess in nutrient supply, the chronic flux of FFAs promotes a state of lipotoxicity across different tissues (11)

Bottiglieri, T., Laundy, M., Crellin, R., Toone, B

Cell Struct Funct 28(5):419429

How This Works The intestinal lining is a single layer of epithelial cells sealed together by tight junctions that control the paracellular pathway the space between cells and thereby regulate what passes from the gut lumen into the tissue