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Alternatively, the second model posits that all four G subunits are necessary for channel activation

Aging 14 , 60066027 (2022)

doi:10.1016/s0169-328x(99)00091-1

This pathway increases NO production, essential for endothelial proliferation, vessel dilation, and new capillary formation, which may be particularly beneficial in ischemic or hypovascular musculoskeletal tissues [20, 24, 26, 39, 41]