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Lee et al., 2016

A recent study showed that TMAO induces osteogenic responses in human aortic valve interstitial cells via ERmitochondrial stress in vitro and aggravates aortic valve lesions in mice (72)

This was previously exacerbated by gastro intestinal manifestations not being included in clinical criteria for hypermobility conditions and hypermobility type EDS (hEDS)

Malnutrition is associated with increased diaphragmatic diastolic ratio, decreased muscle weight, decreased fibre size, decreased percentage of type II fibre, and consumption of energy-rich compounds (Orozco-Levi, 2003)

For patients with Long COVID and dysautonomia experiencing severe cardiovascular strain, providing this targeted metabolic support to the heart is highly relevant