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Lastly, to investigate downstream mechanisms, CXCL13, a known POU2F1 target gene, was significantly downregulated in CTNNB1-mutated HCC patients from three independent cohorts

Nutrient stress-response proteins Limiting glutamine utilization regulates nutrient stress-response proteins and transcription factors

Ferroptosis is a multifactorial process involving iron metabolism, lipid peroxidation, and antioxidant defense systems

These combination strategies demonstrate strong synergistic effects, laying a robust theoretical foundation for the development of personalized treatment strategies

While these pathways are theoretically relevant to soft-tissue recovery, orthopaedic-specific evidence remains minimal

Sol-Gel Zone (Cytoskeletal Matrix): Forms the cytoplasmic matrix, rich in microtubules and microfilaments (actin), responsible for maintaining platelet shape and facilitating structural changes