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GSH levels and their related enzyme activities, such as the activities of GPx and GR, are higher in cultured microglia than in cultured astrocytes and neurons, especially under oxidative stress conditions [85,86]

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These studies revealed that DSePA was not an efficient GPx mimic and its ability to catalyze the detoxification of hydroperoxides through the GPx cycle was considerably lower than ebselen [82, 83]

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doi:10.1155/2013/180906 Jeong W, Bae SH, Toledano MB, Rhee SG (2012) Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression

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