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J Thorac Cardiovasc Surg 167(2):478-487.e2, 2024

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Recent studies found that elevated intracellular iron increases pTau and its aggregation, linking tauopathies to dysfunctional ELS (Rao and Adlard, 2018)

activation of presynaptic 2 receptors in the brainstem reduces sympathetic outflow , lowering blood pressure (see clonidine) methyldopa's effect also produce a reduction of plasma renin levels, which contributes to its antihypertensive effects Figure 1