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Additionally, HSPA12A has been shown to play a crucial role in myocardial protection by maintaining aerobic glycolysis homeostasis in cardiomyocytes and regulating histone 3 lactylation, thus alleviating myocardial IRI [91]

144 One explanation for this is that the final AUC for the active metabolites is unaffected, which is supported by the demonstration that cyclophosphamide given iv over 90 min yields 4-hydroxycyclophosphamide AUC of 105110 mol/L that is similar to an AUC when the dose is infused over 4 days

Increased erythrocyte phosphatidylserine exposure in sickle cell disease: flow-cytometric measurement and clinical associations

Hill JR, Kuriyama N, Kuriyama H, Israel MA

Thioredoxins in chloroplasts