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Mechanical stress can damage the tripeptide (although as a smaller molecule its mechanical sensitivity is lower than that of large peptides)

Various augmenting agents were tested (buspirone, memantine, suvorexant, gabapentin, and pregabalin)

When you take things out of the food matrix and you put a single ingredient into a pill, it doesn't have the same effect, says Katherine Tucker, director of the Center for Population Health at the University of Massachusetts Lowell