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This reduces cystine uptake, GSH synthesis, and GPX4 levels, inducing ferroptosis and ultimately increasing HCC sensitivity to radiotherapy (85)

Table 2 Genetic defects in the riboflavin pathway and their clinical implications

Acknowledgements The authors gratefully acknowledge Dr

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This does not diminish the importance of kynurenine limitation, instead, it highlights the need for precise patient stratification, optimized combination strategies, targeting additional pathway nodes, or directly inhibiting AhR with antagonists