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Whether the acute meal terminating effects of bupropion documented in animal studies could be translated into long-term weight loss efficacy in humans was addressed by three clinical trials with overweight and obese adults (55, 56, 57) using different treatment doses (100 to 400 mg/d) and duration (up to 24 weeks)

The body will remove any excess of the vitamin through the urine

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The compound appears to work primarily by preventing the metabolic "drain" that NNMT imposes on adipose tissue, allowing fat cells to burn energy more efficiently